Nytol is a sleeping aid that can help to treat short-term sleeplessness and insomnia. In this guide, we will be answering common questions we are regularly asked about Nytol such as ‘how does Nytol work’, providing comprehensive information on the medication to help you decide if Nytol is suitable for you and how to purchase it at Pharmacy Prime. 


This Nytol guide covers all of the essential information on this medication. Here, you will find details on what Nytol is, what it’s used for, whether it’s suitable for you and the Nytol products available to order online at Pharmacy Prime. This guide will answer:

  • What is Nytol?
  • What is Nytol used for?
  • How does Nytol work?
  • How to take Nytol
  • How long does Nytol take to work?
  • How long can you take Nytol?
  • Is Nytol safe?
  • Potential side effects
  • Contraindications
  • Buy Nytol at Pharmacy Prime

What is Nytol?

Nytol is a branded name for the medication diphenhydramine. It is commonly used as a sleeping aid for those having trouble sleeping due to its drowsy effect.

What is Nytol used for?

Nytol is used to remedy temporary sleep disturbance, in the form of short-term sleeplessness and insomnia, by making the user fall asleep more easily. It is not intended for treating long-term insomnia as it shouldn’t be taken for an extended period.

How does Nytol work?

Nytol is an antihistamine, meaning it works to block the effects of histamine. Histamine stimulates the areas of the brain that promote arousal, so Nytol induces drowsiness by blocking it which makes falling asleep much easier.

How to take Nytol

Nytol is usually taken orally as a tablet but is also available as a liquid. It is typically taken just before bed once a day, though the amount taken can vary depending on the strength. You should only take Nytol as instructed by the patient information leaflet or under your doctor's or pharmacist’s advice.


Nytol is most commonly taken as a 50mg dose for adults and children aged over 16. One tablet is taken before bed each night.

How long does Nytol take to work?

You should take Nytol around 20 to 30 minutes before going to bed as the effects of the medication will set in after this time.

How long can you take Nytol?

Nytol is intended to treat occasional sleeplessness. You should not take Nytol for longer than two weeks. If your symptoms last longer than this period, you should speak to your GP for further advice.

Is Nytol safe?

Nytol is a safe medication to use as diphenhydramine has been used to treat sleeplessness for decades. As with many medications, however, there is a risk of side effects, which are discussed below.

Potential side effects

Like all medications, Nytol has several side effects that could occur as a result of its use. The most common side effects include:

  • Dizziness
  • Drowsiness
  • Dry mouth
  • Fatigue

This list of side effects is not exhaustive. You should refer to the patient information leaflet included with the medication for further details and call 111 for a doctor’s advice if you experience any side effects mentioned.


If you experience any symptoms of severe side effects or an allergic reaction as described below, you should seek immediate medical attention by calling 999:

  • Difficulty breathing
  • Swelling of the face, lips, tongue, or throat
  • A rash


Nytol is generally suitable for most adults. However, it should not be taken by those who:

  • Are allergic to diphenhydramine or any of its ingredients
  • Are under the age of 16
  • Are pregnant or breastfeeding
  • Suffer from seizures or epilepsy
  • Have narrow-angle glaucoma
  • Have liver or kidney problems

If you intend to take Nytol and fall under any of these categories, you should first consult your doctor before doing so.

This list is not exhaustive. If you have any health conditions or are taking any medication that could potentially interfere with using Nytol, you should refer to a pharmacist’s or doctor’s advice before you do so.

Buy Nytol at Pharmacy Prime

If you are looking to use diphenhydramine and know it is safe for you to do so, you can purchase sleeping tablets at Pharmacy Prime at competitive prices. You can buy Nytol from our online store in the following forms:


The Nytol range includes natural remedies that can also be useful in helping you get better rest. These include:


If you are struggling with sleep, it is possible to get prescription insomnia medication at Pharmacy Prime through our online clinic service. Through this service, you will be provided the relevant medication for you as chosen by one of our pharmacists after having your symptoms assessed. There is not one medication you may be prescribed, as the appropriate medication can differ from person to person depending on their circumstances.

Contact us

We hope this guide on Nytol has helped you know more about the medication and see if it’s suitable for you. If you would like to know more about the different medications we provide at Pharmacy Prime or have any other enquiries relating to our products, please get in touch with us. A member of our friendly team will be in touch to provide you with assistance.